Reaktion #41798

Reaktionsgleichung

N-methylpiperazine

NMP

triethylamine

5-fluoro-2-nitrophenylamine

→

5-(4-Methyl-piperazin-1-yl)-2-nitro-phenylamine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting solid was collected
2. 2
   Sonstigedried
3. 3
   Sonstigeutilized without further purification

Vorschrift

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.

Quelle