Reaktion #417970

Reaktionsgleichung

Acetic acid

25b

1-bromo-4-nitro-2-(2-phenoxy-ethoxy)-benzene

→

aniline

Ausbeute 84.0%

4-bromo-3-(2-phenoxy-ethoxy)-phenylamine

Ausbeute 84.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   Sonstigethe crude was purified by flash column chromatography

Vorschrift

Acetic acid (1.068 mL, 18 mmol) was added to the mixture of 25b (600 mg, 1.8 mmol) and zinc dust (1.157 g, 18.0 mmol) in ethanol (10 mL) at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hrs. The mixture was filtered, the solvent distilled off under reduced pressure and the crude was purified by flash column chromatography to obtain the aniline 25c in 84% yield.

Quelle