Reaktion #417969

Reaktionsgleichung

BBr3

1-bromo-2-methoxy-4-nitrobenzene

→

desired compound

Ausbeute 65.0%

2-bromo-5-nitro-phenol

Ausbeute 65.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was quenched with water
2. 2
   Extraktionextracted with ethyl acetate (3×20 mL)
3. 3
   SonstigeThe combined extracts were dried
4. 4
   Sonstigethe crude was purified by flash column chromatography

Vorschrift

BBr3 (8.58 mL of 1.0M solution, 8.6 mmol) was added to the DCM (10 mL) solution of 1-bromo-2-methoxy-4-nitrobenzene (1.0 g, 4.3 mmol) at 0° C. The reaction mixture was warmed to room temperature and stirred overnight. The mixture was quenched with water and extracted with ethyl acetate (3×20 mL). The combined extracts were dried and the crude was purified by flash column chromatography to get the desired compound as pale brown powder in 65% yield (600 mg).

Quelle