Reaktion #417964

Reaktionsgleichung

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

Ausbeute 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

Ausbeute 93.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction was refluxed for 5 mins
2. 2
   FiltrationIt was filtered off
3. 3
   Waschenwashed with water (10 mL)
4. 4
   Sonstigedried

Vorschrift

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

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