Reaktion #41796

Reaktionsgleichung

2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine

{4-[2-methoxy-4-(methylamino)-5-nitrophenoxy](2-pyridyl)}-N-methylcarboxamide

EtOH

→

4-(3-Pyrrolidinylpropoxy)benzene-1,2-diamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction vessel is repeatedly purged (×3) with nitrogen
2. 2
   FiltrationThe product is filtered through a Celite plug
3. 3
   Waschenthe plug washed with 25 mL of EtOH
4. 4
   Sonstigeto yield 2

Vorschrift

To a solution 2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine 1 in EtOH, Pd/C (0.1 eq) is added. The reaction vessel is repeatedly purged (×3) with nitrogen, and then stirred under a hydrogen atmosphere for 18 h. The product is filtered through a Celite plug, and the plug washed with 25 mL of EtOH, to yield 2. LCMS 236.2 Rt 0.94 min.

Quelle