Reaktion #417952

Reaktionsgleichung

dimethyl sulfone

sodium-bis-(trimethylsilyl)-amide

THF

2-bromo-6-fluoropyridine

→

2-Bromo-6-(1-methanesulfonyl-cyclopropyl)-pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction is quenched by the addition
2. 2
   ExtraktionNaCl solution and extracted with EtOAc
3. 3
   TrocknenThe organic layer is dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Sonstigethe solvent is removed in vacuo

Vorschrift

Under inert gas atmosphere 28.4 mL (56.8 mmol) of a sodium-bis-(trimethylsilyl)-amide solution in THF (c=2 mol/L) are chilled to −17° C. and dropwise charged with 2.00 g (11.3 mmol) 2-bromo-6-fluoropyridine. Afterwards 2.14 g (22.7 mmol) dimethyl sulfone are added and the reaction mixture is stirred at −17° C. for 1 h. The reaction is quenched by the addition of aq. sat.NaCl solution and extracted with EtOAc. The organic layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

Quelle