Reaktion #417951

Reaktionsgleichung

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   Filtrationthe resulting mixture is filtered
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered again
6. 6
   Sonstigethe solvent is removed in vacuo

Vorschrift

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

Quelle