Reaktion #417946

Reaktionsgleichung

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction is quenched by the addition of water
2. 2
   Extraktionextracted with DCM
3. 3
   Trocknenlayers are dried over MgSO4
4. 4
   Filtrationfiltered

Vorschrift

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

Quelle