Reaktion #417943

ord-10572e9e42914c269065c8e47baaf881

Reaktionsgleichung

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

Edukte

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride

Reagenzien

Keine

Lösungsmittel

ClCCl
DCM

Reaktionsbedingungen

Temperatur
25°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThen the cooling is removed
  2. 2
    WaschenAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
  3. 3
    Trocknenlayer is dried over MgSO4
  4. 4
    Filtrationfiltered
  5. 5
    Sonstigethe solvent is removed in vacuo

Vorschrift

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08877741B2uspto-grants-2014_11