Reaktion #417802

Reaktionsgleichung

VII

6-(N-Carbobenzoxy-L-alanyl-L-alanylamino)quinoline

methyliodide

→

1-Methyl-6-(N-carbobenzoxy-L-alanyl-L-alanylamino) quinoline Iodide

Ausbeute 90.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent and alkylating agent were removed in vacuo
2. 2
   Sonstigeto afford a thick orange oil
3. 3
   SonstigeCrystallization from ethanol-ether
4. 4
   Sonstigeproduced 36 mg (90% yield)

Vorschrift

To 29 mg (0.06 mmol) of VII in 5 ml of chloroform was added 1 ml of methyliodide. After the mixture was stirred for 24 hours at room temperature, the solvent and alkylating agent were removed in vacuo to afford a thick orange oil. Crystallization from ethanol-ether produced 36 mg (90% yield), of a finely divided yellow powder: mp 135° C. decomposes; Rf(E)=0.06. Analysis calculated for C24H27N4O4I: C, 51.26; H, 4.84; N, 9.96. Found: C, 50.05; H, 5.23; N, 9.85. Fast atom bombardment mass spectrum: calculated for MW (435)+I-. Found: 435 (M+).

Quelle