Reaktion #41733

Reaktionsgleichung

2-chloro-5-methoxybenzoxazole

4-bromoaniline

diisopropylethylamine

→

(4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resultant mixture was concentrated
2. 2
   Sonstigepartitioned between ethyl acetate and water
3. 3
   WaschenThe organic layer was washed with brine
4. 4
   Sonstigedried
5. 5
   SonstigePurification on silica gel

Vorschrift

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

Quelle