Reaktion #41722

Reaktionsgleichung

2-[(4-bromophenyl)amino]benzothiazol-5-ol

Potassiumbis(trimethylsilyl)amide

4-chloro(2-pyridyl)-N-methylcarboxamide

Potassium carbonate

→

desired product

(4-{2-[(4-bromophenyl)amino]benzothiazol-5-yloxy}(2-pyridyl))-N-methylcarboxamide

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigemicrowaved for 6 mins at 150° C
2. 2
   EinengenThe reaction mixture was then concentrated
3. 3
   Sonstigepartitioned between ethyl acetate and water
4. 4
   SonstigeThe organic layer was separated
5. 5
   Waschenwashed with brine
6. 6
   Sonstigedried
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated
9. 9
   SonstigePurification on Prep LC

Vorschrift

The mixture containing 2-[(4-bromophenyl)amino]benzothiazol-5-ol (1 eq), Potassiumbis(trimethylsilyl)amide (4 eq), was stirred in dimethylformamide for 30 min at room temperature. To this mixture was added (4-chloro(2-pyridyl)-N-methylcarboxamide (1 eq) and Potassium carbonate (1.2 eq) and microwaved for 6 mins at 150° C. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with brine, dried, filtered and concentrated. Purification on Prep LC yielded the desired product. MS: MH+=455

Quelle