Reaktion #41720

Reaktionsgleichung

2-bromo-5-methoxybenzthiazole

4-Bromoaniline

→

desired product

(4-bromophenyl)(5-methoxybenzothiazol-2-yl)amine

Lösungsmittel

NMP

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resultant mixture was concentrated
2. 2
   Sonstigepartitioned between ethyl acetate and water
3. 3
   WaschenThe organic layer was washed with brine
4. 4
   Sonstigedried
5. 5
   SonstigePurification on silica gel

Vorschrift

The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335

Quelle