Reaktion #4170

Reaktionsgleichung

9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one

4-methylpiperidine

→

product

Ausbeute 83.0%

9-Bromo-6-(4-methyl-1-piperidinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

Ausbeute 83.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated under nitrogen
2. 2
   Sonstigeresulted
3. 3
   TemperaturThe mixture was refluxed for 3 hours
4. 4
   Filtrationfiltered
5. 5
   workup.STIRRINGThe filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes
6. 6
   Sonstigethe layers were separated
7. 7
   ExtraktionThe aqueous phase was extracted with 250 ml of toluene
8. 8
   Waschenwashed once with 2N sodium hydroxide solution, twice with water
9. 9
   Trocknendried over anhydrous sodium sulfate
10. 10
    Filtrationfiltered
11. 11
    Einengenconcentrated in vacuo to an oil which
12. 12
    SonstigeThe solid was triturated twice with hexane

Vorschrift

A mixture of 4.73 g (0.0150 mole) of 9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one and 1000 ml of toluene was heated under nitrogen, with stirring, until a solution resulted. Then there was added 14.9 g (0.150 mole) of 4-methylpiperidine, followed by 8.54 g (0.045 mole) of titanium tetrachloride. The mixture was refluxed for 3 hours, cooled to room temperature and filtered. The filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes and the layers were separated. The aqueous phase was extracted with 250 ml of toluene. The toluene layers were combined, washed once with 2N sodium hydroxide solution, twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to an oil which solidified. The solid was triturated twice with hexane to afford 4.9 g (83%) of product. Recrystallization from ethyl acetate provided the analytical sample, mp 177°-179° C.

Quelle