Reaktion #41671

Reaktionsgleichung

sodium bicarbonate

sodium borohydride

N-(3-fluoro-4-(2-(2-hydroxyethyl)acryloyl)phenyl)pyridine-2-carboxamide

→

N-(4-(1,4-dihydroxy-2-methylbutyl)-3-fluorophenyl)pyridine-2-carboxamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   Extraktionextracted with chloroform
3. 3
   Trocknendried with anhydrous sodium sulfate
4. 4
   SonstigeThe solvent was evaporated away under reduced pressure
5. 5
   Sonstigethe resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=100/1)
6. 6
   Sonstigeto obtain the entitled compound as a colorless oily substance

Vorschrift

150 mg of sodium borohydride was added to a methanol (8 ml) solution of 320 mg of N-(3-fluoro-4-(2-(2-hydroxyethyl)acryloyl)phenyl)pyridine-2-carboxamide, and the reaction liquid was stirred at room temperature for 1 hour. Aqueous saturated sodium bicarbonate was added to the reaction liquid, extracted with chloroform, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=100/1) to obtain the entitled compound as a colorless oily substance.

Quelle