Reaktion #41669

ord-14c0c2104d9d4b868d1102d3db6bba65

Reaktionsgleichung

CS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2C2CCCN2)cc1
5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole
CC(C)(C)OC(=O)NCC(=O)O
N-t-butoxycarbonyl-glycine
→
CCOC(=O)NCC(=O)N1CCCC1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(S(C)(=O)=O)cc1
Ethyl (2-(2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-carbamate

Edukte

CS(=O)(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2C2CCCN2)cc1
5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole
CC(C)(C)OC(=O)NCC(=O)O
N-t-butoxycarbonyl-glycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method

Vorschrift

The entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method or by combining it with an ordinary method but using 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) and N-t-butoxycarbonyl-glycine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728025B2uspto-grants-2010_06