Reaktion #416613

ord-2dd1b797f7c845f08bd0654c2c56b35f

Reaktionsgleichung

CC(=O)Oc1cc2c(nc1C)C(=O)OC2=O
5-acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride
CC(C)[C@](C)(N)C(N)=O
2-methyl-valinamide
→
CC(=O)Oc1cc(C(=O)O)c(C(=O)NC(C)(C(N)=O)C(C)C)nc1C
5-acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid

Edukte

CC(=O)Oc1cc2c(nc1C)C(=O)OC2=O
5-acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride
CC(C)[C@](C)(N)C(N)=O
2-methyl-valinamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Filtrationthe precipitated crystalline product is filtered off

Vorschrift

6.3 g (28.48 mmol) 5-acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride and 4.1 g (31.33 mmol) 2-methyl-valinamide are stirred under nitrogen for 2 days at room temperature, and then the precipitated crystalline product is filtered off.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04891428uspto-grants-1990_01