Reaktion #41660

Reaktionsgleichung

t-butyldimethylsilyl chloride

imidazole

dimethylformamide

3-hydroxydihydrofuran-2-(3H)-one

→

3-((t-butyl(dimethyl)silyl)oxy)dihydrofuran-2 (3H)-one

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   SonstigeThe reaction liquid
3. 3
   Waschenwashed with water
4. 4
   Trocknendried with anhydrous sodium sulfate
5. 5
   SonstigeThe solvent was evaporated away under reduced pressure
6. 6
   Sonstigethe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)
7. 7
   Sonstigeto obtain the entitled compound as a colorless oily substance

Vorschrift

9.0 g of imidazole and 15.9 g of t-butyldimethylsilyl chloride were added in order to a dimethylformamide (180 ml) solution of 9.0 g of 3-hydroxydihydrofuran-2-(3H)-one, and the reaction liquid was stirred for 1 hour at room temperature. The reaction liquid was diluted with ethyl acetate, washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a colorless oily substance.

Quelle