Reaktion #416585

Reaktionsgleichung

4-(4-(2-chloroethyl)phenyl)-2-methylthiazole hydrobromide

N-(1-naphthyl)piperazine

diisopropylethylamine

sodium carbonate

sodium iodide

→

4-(4-(2-(4-(1-Naphthyl)piperazinyl)ethyl)phenyl)-2-methylthiazole

Lösungsmittel

methylisobutylketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 125 ml round-bottomed flask equipped with condenser and N2 inlet
2. 2
   TemperaturThe reaction was heated
3. 3
   Temperaturat reflux for 5 days
4. 4
   Temperaturcooled
5. 5
   Filtrationthe precipitate filtered
6. 6
   Waschenwashed with sodium bicarbonate
7. 7
   Trocknendried over sodium sulfate
8. 8
   workup.ADDITIONtreated with methylene chloride saturated with hydrochloride
9. 9
   Sonstigeevaporated
10. 10
    Sonstigethe residue triturated with ether
11. 11
    Sonstigeto afford a white solid, m.p. 305°-307° C., 1.76 g (48%)

Vorschrift

To a 125 ml round-bottomed flask equipped with condenser and N2 inlet were added 2.39 g (7.5 mmol) of 4-(4-(2-chloroethyl)phenyl)-2-methylthiazole hydrobromide, 1.59 g (7.5 mmol) of N-(1-naphthyl)piperazine, 1.31 ml (7.5 mmol) of diisopropylethylamine, 1.59 g (15 mmol) of sodium carbonate, 5 mg of sodium iodide, and 50 ml of methylisobutylketone. The reaction was heated at reflux for 5 days, cooled, and the precipitate filtered. The solid was taken up in methylene chloride, washed with sodium bicarbonate, dried over sodium sulfate, treated with methylene chloride saturated with hydrochloride, evaporated, and the residue triturated with ether to afford a white solid, m.p. 305°-307° C., 1.76 g (48%).

Quelle