Reaktion #416568

Reaktionsgleichung

2-bromo-1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone

1-amino-2-thioxo-5-imidazolidinone

1-Amino-2-thioxo-5-imidazolidinone

→

3-(3,5-Di-tert.butyl-4-hydroxyphenyl)-6-oxo-6,7-dihydro-2H-imidazo[2,1-b][1,3,4]thiadiazine hydrobromide

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationthe precipitate was filtered off
3. 3
   Waschenwashed with 250 ml of ethyl acetate
4. 4
   Trocknenthe crystals were dried in vacuo over phosphorus pentoxide

Vorschrift

34.4 g (0.11 mol) of 2-bromo-1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone from Example 1(a) and 13.8 g (0.11 mol) of 1-amino-2-thioxo-5-imidazolidinone from step (a) were heated at 90° C. for 30 minutes in 300 ml of glacial acelic acid. After cooling, the precipitate was filtered off and washed with 250 ml of ethyl acetate, and the crystals were dried in vacuo over phosphorus pentoxide.

Quelle