Reaktion #416398

ord-49abff0ab6134960a4a17e04072b4618

Reaktionsgleichung

NCCSC12CC3CC(CC(C3)C1)C2
2-(1-adamantylthio)ethylamine
C[O-].[Na+]
sodium methoxide
CC(C)(C)C(Br)C(=O)O
2-bromo-2-tert-butyl acetic acid
→
CC(C)(C)C(NCCSC12CC3CC(CC(C3)C1)C2)C(=O)O
2-tert-butyl-N-[2-(1 -adamantylthio)ethyl-]glycine

Edukte

—
42.3
NCCSC12CC3CC(CC(C3)C1)C2
2-(1-adamantylthio)ethylamine
C[O-].[Na+]
sodium methoxide
CC(C)(C)C(Br)C(=O)O
2-bromo-2-tert-butyl acetic acid

Reagenzien

Keine

Lösungsmittel

CC(C)(C)O
tert-butanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturis refluxed, under a nitrogen atmosphere, for 5 hours
  2. 2
    SonstigeThe product is recovered in the manner

Vorschrift

A mixture of 42.3 parts of 2-(1-adamantylthio)ethylamine, 10.8 parts of sodium methoxide, 39.0 parts of 2-bromo-2-tert-butyl acetic acid and 315 parts of tert-butanol is refluxed, under a nitrogen atmosphere, for 5 hours. The product is recovered in the manner described in Example 5 to yield 2-tert-butyl-N-[2-(1 -adamantylthio)ethyl-]glycine, melting at about 220°-230°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04020079uspto-grants-1977_04