Reaktion #416067

Reaktionsgleichung

1-ethyl-3-azetidinol

α-naphthol

potassium hydroxide

→

1-(α-naphthoxy)-3-ethylamino-2-propanol

Ausbeute 70.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   Extraktionextracted with ether
4. 4
   ExtraktionThe ether extract
5. 5
   Waschenwas washed with 2N-NaOH aqueous solution
6. 6
   TrocknenThe liquor was dried over anhydrous sodium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off
8. 8
   SonstigeThe residue was recrystallized from cyclohexane

Vorschrift

To a mixture of 10.2 parts of 1-ethyl-3-azetidinol and 14.4 parts of α-naphthol 0.2 part of potassium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The ether extract was washed with 2N-NaOH aqueous solution and then with water. The liquor was dried over anhydrous sodium sulfate and the solvent was distilled off. The residue was recrystallized from cyclohexane to yield 17.2 parts of 1-(α-naphthoxy)-3-ethylamino-2-propanol. The melting of the product was 106°-107° C. The yield was 70%.

Quelle