Reaktion #415952

Reaktionsgleichung

Thionyl chloride

ethyl 8-(2-hydroxyethylthio)-12-acetoxyheptadecanoate

→

title compound

ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution is heated
2. 2
   Temperaturat reflux for 2 hours
3. 3
   SonstigeThen, the solvent and excess thionyl chloride are removed by evaporation in vacuo

Vorschrift

Thionyl chloride (13.1 g., 0.11 mole) is added dropwise with stirring to a solution of ethyl 8-(2-hydroxyethylthio)-12-acetoxyheptadecanoate (43.2 g., 0.10 mole) in benzene (150 ml.). The solution is heated at reflux for 2 hours. Then, the solvent and excess thionyl chloride are removed by evaporation in vacuo to leave the title compound as an orange yellow residual oil.

Quelle