Reaktion #415918

ord-10016eeba5894e59b1373c9c75dfca94

Reaktionsgleichung

N#Cc1ccc(C=O)s1
5-cyano-thiophen-2-aldehyde
N#Cc1ccc(C=O)s1
5-cyan0-thiophen-2-aldehyde
N#Cc1ccc(C=O)s1
5-cyano-thiophen-2-aldehyde
N#Cc1ccc(C=O)s1
5-cyano-thiophen-2-aldehyde
Br.C=CCSC(=N)NN=Cc1ccc(C#N)s1
5-Cyano-thiophen-2-aldehyde-S-allyl-isothiosemicarbazone-hydrobromide
N#Cc1ccc(C=NNC(N)=S)s1
5-cyano-thiophen-2-aldehyde-thiosemicarbazone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn the same manner, there were obtained
  2. 2
    Sonstigewith good yields

Vorschrift

In the same manner, there were obtained with good yields: 2. 5-Cyano-thiophen-2-aldehyde-S-ethyl-isothiosemicarbazonehydroiodide melting at 145° C (free base 94° C) from 5-cyan0-thiophen-2-aldehyde and S-ethyl-isothiosemicarbazide-hydroiodide. 3. 5-Cyano-thiophen-2-aldehyde-S-n-propyl-isothiosemicarbazonehydroiodide melting at 174° C (free base 75° C) from 5-cyano-thiophen-2-aldehyde and S-n-propyl-isothiosemicarbazide-hydroiodide. 4. 5-Cyano-thiophen-2-aldehyde-S-allyl-isothiosemicarbazone-hydrobromide melting at 169° C (free base 126° C) from 5-cyano-thiophen-2-aldehyde and S-allyl-isothiosemicarbazide-hydrobromide. 5. 5-Cyano-thiophen-2 -aldehyde-S-benzyl-isothiosemicarbazonehydrobromide melting at 208° C (free base 130° C) from 5-cyano-thiophen-2-aldehyde and S-benzyl-isothiosemicarbazide-hydrobromide. 6. The above-mentioned compounds were also obtained by the reaction of 5-cyano-thiophen-2-aldehyde-thiosemicarbazone with the corresponding alkyl- or aralkyl-halides in ethylene-glycol-monomethyl ether at 50° -60° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04018792uspto-grants-1977_04