Reaktion #415812

Reaktionsgleichung

2-allyl-4-fluorophenol

1,3-dibromopropane

sodium hydroxide

→

3-allyl-4-(3-bromopropoxy)fluorobenzene

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxing
2. 2
   workup.STIRRINGUpon completion, the whole is stirred
3. 3
   Temperaturrefluxed for 8 hours
4. 4
   TemperaturAfter cooling
5. 5
   Sonstigethe aqueous layer is separated
6. 6
   Extraktionextracted with chloroform
7. 7
   TrocknenThe extract is dried over magnesium sulfate
8. 8
   Filtrationfiltered
9. 9
   Sonstigeevaporated
10. 10
    workup.DISTILLATIONThe oily residue is distilled twice

Vorschrift

To a stirred and refluxing mixture of 162 parts of 2-allyl-4-fluorophenol, 363 parts of 1,3-dibromopropane in 700 parts of water is added dropwise a solution of 56 parts of sodium hydroxide in 175 parts of water. Upon completion, the whole is stirred and refluxed for 8 hours. After cooling, the aqueous layer is separated and extracted with chloroform. The extract is dried over magnesium sulfate, filtered and evaporated. The oily residue is distilled twice, yielding 142 parts of 3-allyl-4-(3-bromopropoxy)fluorobenzene; bp. 160° -170° C. at 14 mm. pressure.

Quelle