Reaktion #41567

Reaktionsgleichung

ethanol

1-(2-(5-amino-2-(4-fluoro-phenoxy)-4-nitro-phenyl)-piperidin-1-yl)-ethanone

pyridine-2-carboxaldehyde

hydrogen

→

compound

1-(2-(6-(4-fluoro-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-piperidin-1-yl)-ethanone

Lösungsmittel

Water

N-methylpyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   SonstigeThe catalyst was removed through filtration through Celite
3. 3
   workup.DISTILLATIONthe filtrate was distilled under reduced pressure
4. 4
   Sonstigeto obtain 171 mg of a crude product
5. 5
   Sonstigethe reaction liquid
6. 6
   Extraktionextracted with ethyl acetate
7. 7
   Waschenthe organic layer was washed with water and saturated saline
8. 8
   Trocknendried with anhydrous sodium sulfate
9. 9
   SonstigeThe solvent was evaporated away under reduced pressure
10. 10
    Sonstigethe reaction mixture was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid]

Vorschrift

50 mg of developed Raney nickel catalyst was added to an ethanol (10 ml) solution of 180 mg of 1-(2-(5-amino-2-(4-fluoro-phenoxy)-4-nitro-phenyl)-piperidin-1-yl)-ethanone, and the reaction liquid was stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration through Celite, and the filtrate was distilled under reduced pressure to obtain 171 mg of a crude product. 50 mg of the resulting crude product was dissolved in 1 ml of N-methylpyrrolidone, and 16 mg of pyridine-2-carboxaldehyde was added to it, and the reaction liquid was stirred at room temperature for 3 days. Water was added to the reaction liquid, and extracted with ethyl acetate, and the organic layer was washed with water and saturated saline, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the reaction mixture was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid] to obtain the entitled compound as a pale yellow solid.

Quelle