Reaktion #415417

Reaktionsgleichung

isopropylamine

1-[o-(pyrrol-1-yl)-phenoxy]-2,3-epoxy-propane

→

1-iso-propylamino-3[o-(pyrrol-1-yl)-phenoxy]-2-propanol

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated to the boil
2. 2
   Temperaturunder reflux for 1 1/2 hours
3. 3
   Sonstigeafter evaporating off the volatile constituents in vacuo
4. 4
   workup.DISTILLATIONis distilled in a bulb tube under a high vacuum

Vorschrift

50 ml of isopropylamine are added to a solution of 26.9 g of 1-[o-(pyrrol-1-yl)-phenoxy]-2,3-epoxy-propane in 250 ml of isopropanol and the mixture is heated to the boil under reflux for 1 1/2 hours. The oil which remains after evaporating off the volatile constituents in vacuo is distilled in a bulb tube under a high vacuum and gives 1-iso-propylamino-3[o-(pyrrol-1-yl)-phenoxy]-2-propanol as a colourless oil of boiling point 125°-135° C/0.04 mm Hg. The distillate which crystallises can be recrystallised from ether/petroleum ether and gives crystals of melting point 80°-81° C and is in every respect identical with the product obtained in Example 3.

Quelle