Reaktion #415360

Reaktionsgleichung

oxetane

N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide

→

3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 20 g
2. 2
   SonstigeThe solution is evaporated in vacuo
3. 3
   workup.DISSOLUTIONthe residue is dissolved in 50 ml
4. 4
   Filtrationof acetonitrile and filtered
5. 5
   SonstigeUpon evaporation the desired product
6. 6
   Sonstigecrystallizes
7. 7
   SonstigeThe product may be recrystallized from acetonitrile

Vorschrift

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

Quelle