Reaktion #415354

Reaktionsgleichung

hydrochloric acid

acetyl chloride

aluminum chloride

Cyclohexylbenzene

→

p-cyclohexylacetophenone

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling in an ice-bath
2. 2
   Sonstigethe temperature below 5°
3. 3
   workup.ADDITIONAfter addition
4. 4
   workup.STIRRINGthe product is stirred for another hour before hydrolyzing
5. 5
   workup.STIRRINGwith stirring
6. 6
   WaschenThe organic phase is washed with successive portions of dilute hydrochloric acid, sodium carbonate, and water
7. 7
   workup.DISTILLATIONdistilled

Vorschrift

To a suspension of anhydrous aluminum chloride (467 g,; 3.5 moles) in carbon tetrachloride (2 l.) is added acetyl chloride (275 g.; 249 cc., 3.5 moles) during 15 minutes with vigorous stirring and cooling in an ice-bath. Cyclohexylbenzene (481 g.; 3.0 moles) is added dropwise over a period of 3 hours, keeping the temperature below 5°. After addition is complete, the product is stirred for another hour before hydrolyzing by pouring into ice and hydrochloric acid with stirring. The organic phase is washed with successive portions of dilute hydrochloric acid, sodium carbonate, and water, and distilled to give p-cyclohexylacetophenone, (b.p. 88°-95.5°/ 0.05 mm.).

Quelle