Reaktion #41528

Reaktionsgleichung

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   SonstigeThe reaction liquid
3. 3
   Waschenwashed with water and saturated saline in order
4. 4
   Trocknendried with anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was evaporated away under reduced pressure
6. 6
   Sonstigeto obtain the entitled compound

Vorschrift

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

Quelle