Reaktion #41460

Reaktionsgleichung

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

Ausbeute 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Ausbeute 98.0%

Lösungsmittel

Water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe beige-orange precipitate that formed
2. 2
   Sonstigewas collected by,
3. 3
   Filtrationfiltration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried in vacuo

Vorschrift

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

Quelle