Reaktion #41456

Reaktionsgleichung

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Ausbeute 98.1%

Lösungsmittel

Water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe light yellow precipitate that formed
2. 2
   Filtrationwas collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried in vacuo

Vorschrift

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

Quelle