Reaktion #41455

Reaktionsgleichung

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

potassium tert-butoxide

HCl

→

4-(5-iodo-1H-indazol-1-yl)benzoic acid

Ausbeute 94.1%

Lösungsmittel

NMP

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was then cooled
2. 2
   SonstigeThe precipitate that formed
3. 3
   Filtrationwas collected by filtration
4. 4
   Sonstigedried in vacuo

Vorschrift

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (141d, 3.42 g, 8.9 mmol) and potassium tert-butoxide (2.29 g, 20.5 mmol) was stirred under argon atmosphere in NMP (45 mL) at 150° C. for 15 min. The mixture was then cooled, diluted with water and acidified with aqueous HCl (1.7 M). The precipitate that formed was collected by filtration and dried in vacuo to give crude 4-(5-iodo-1H-indazol-1-yl)benzoic acid (3.05 g, 94%)

Quelle