Reaktion #41446

Reaktionsgleichung

2-methylpropanoyl chloride

2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide

potassium 2-methylpropan-2-olate

→

N-[2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-phenyl-acetyl]-2-methyl-propanamide

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStirring
2. 2
   workup.WAITwas continued for 30 min at 0° C
3. 3
   EinengenThen the sample was concentrated in vacuo
4. 4
   Sonstigepurified by semi-prep
5. 5
   SonstigeHPLC go give white solid material, 14 mg (59%)

Vorschrift

A stirred solution of 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide (137b, 20 mg, 60 μmol) in THF (2 ml) was cooled to 0° C., and potassium 2-methylpropan-2-olate (18.6 mg, 170 μmol) was added. The mixture was stirred at 0° C. for 10 min, and a solution of 2-methylpropanoyl chloride (30 mg, 280 μmol) in THF (0.5 ml) was added. Stirring was continued for 30 min at 0° C. Then the sample was concentrated in vacuo and purified by semi-prep. HPLC go give white solid material, 14 mg (59%).

Quelle