Reaktion #41437

Reaktionsgleichung

5-iodo-1H-indazole

isopropyl bromide

KOtBu

ethyl acetate

→

subtitle compound

Ausbeute 52.0%

5-Iodo-1-isopropyl-1H-indazole

Ausbeute 52.0%

5-iodo-2-isopropyl-2H-indazole

Ausbeute 40.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water (2×50 ml)
2. 2
   Trocknendried with Na2SO4
3. 3
   SonstigeEvaporation of solvent and purification by flash chromatography on silica gel (n-heptane/ethyl acetate)

Vorschrift

A mixture of 5-iodo-1H-indazole (488 mg, 2 mmol), isopropyl bromide (244 mg, 2 mmol), and KOtBu (336 mg, 3 mmol) in dry DMF (4 ml) was stirred at r.t. overnight. Then it was dilited with ethyl acetate (50 ml), washed with water (2×50 ml), and dried with Na2SO4. Evaporation of solvent and purification by flash chromatography on silica gel (n-heptane/ethyl acetate) afforded the subtitle compound (298 mg, 52%) along with 5-iodo-2-isopropyl-2H-indazole (227 mg, 40%).

Quelle