Reaktion #414334

Reaktionsgleichung

sodium imidazole

8-bromo-1-octene

DMF

→

1-(2-bromooctyl)imidazole hydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePartition the reaction product between water and dichloromethane
2. 2
   Sonstigeevaporate the organic layer
3. 3
   Sonstigepurify the resultant residue on a silica gel column
4. 4
   workup.ADDITIONAdd the imidazole compound (4.6 g) and phenol (1 g) to dichloromethane (250 ml)
5. 5
   Einengensaturate the solution with HBr gas
6. 6
   SonstigeEvaporate the solvent
7. 7
   Waschenwash the residue with THF: hexane (1:1)

Vorschrift

Combine sodium imidazole (5 g) and 8-bromo-1-octene (5 g) in DMF and stir overnight. Partition the reaction product between water and dichloromethane, evaporate the organic layer and purify the resultant residue on a silica gel column. Add the imidazole compound (4.6 g) and phenol (1 g) to dichloromethane (250 ml), saturate the solution with HBr gas and stir for 4 hours. Evaporate the solvent and wash the residue with THF: hexane (1:1) to obtain 1-(2-bromooctyl)imidazole hydrobromide.

Quelle