Reaktion #414312

Reaktionsgleichung

Cyanopyrazine

acetic acid

→

methyl pyrazinecarboximidate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONDichloromethane (50 ml) and diethyl ether (50 ml) were added to the concentrated residue, and insolubles
3. 3
   Sonstigewere removed by filtration
4. 4
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

Cyanopyrazine (5.26 g, 50 mmol) was dissolved in methanol (40 ml), and sodium methoxide (0.27 g, 5.0 mmol) was added. The reaction mixture was stirred at room temperature for 45 minutes. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Dichloromethane (50 ml) and diethyl ether (50 ml) were added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl pyrazinecarboximidate (6.87 g) as colorless powder.

Quelle