Reaktion #4139

Reaktionsgleichung

2,5-dibromonitrobenzene

1,2,3,4-tetrahydroquinoline

collidine

→

product

Ausbeute 18.0%

1-(4-Bromo-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline

Ausbeute 18.0%

Lösungsmittel

1,2,3-trimethylbenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Einengenthe filtrate was concentrated in vacuo (100° C.)
3. 3
   Extraktionthe solution was extracted three times with dilute hydrochloric acid
4. 4
   Trocknenonce with dilute sodium hydroxide solution, three times with water, dried over anhydrous sodium sulfate
5. 5
   Einengenconcentrated
6. 6
   workup.DISSOLUTIONThis residue was dissolved in 1:1 hexane
7. 7
   workup.ADDITIONcontaining 3 kg of silica gel
8. 8
   WaschenElution with 1:1 hexane

Vorschrift

A stirred mixture, under nitrogen, of 2,5-dibromonitrobenzene (140.5 g, 0.50 mole), 1,2,3,4-tetrahydroquinoline (133.2 g, 1.00 mole) and symmetrical collidine (121.2 g, 1.00 mole) in 1,2,3-trimethylbenzene (500 ml) as solvent was heated at 160°-165° C. for 7 days. The mixture was cooled to room temperature, filtered, and the filtrate was concentrated in vacuo (100° C.). The residue was taken up in dichloromethane (1.5 l) and the solution was extracted three times with dilute hydrochloric acid, once with dilute sodium hydroxide solution, three times with water, dried over anhydrous sodium sulfate and concentrated. This residue was dissolved in 1:1 hexane:toluene (250 ml) and adsorbed on a chromatography column containing 3 kg of silica gel. Elution with 1:1 hexane:toluene gave 30 g (18%) of product, as an oil. A portion of the oil was Kugelrohr distilled at an oven-temperature of 163°-165° C. (0.1 mm Hg) to provide the analytical sample.

Quelle