Reaktion #413877

Reaktionsgleichung

p-(benzyloxy)-N-[5-(p-chlorophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]benzene-sulfonamide

HCl

→

N-[5-(p-chlorophenyl)-4-pyrimidinyl]-p-hydroxybenzenesulfonamide

Lösungsmittel

acetic acid

dioxane

palladium-carbon

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigeevaporated under reduced pressure
3. 3
   Sonstigethe residue was recrystallized from isopropyl ether and again from CH3CN

Vorschrift

A solution of 512 mg of p-(benzyloxy)-N-[5-(p-chlorophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]benzene-sulfonamide in 30 ml of glacial acetic acid was treated with 2 ml of 4N HCl in dioxane and 100 mg of 10% palladium-carbon. The mixture was hydrogenated while stirring, thereafter the solution was suction filtered, evaporated under reduced pressure and the residue was recrystallized from isopropyl ether and again from CH3CN. There was obtained N-[5-(p-chlorophenyl)-4-pyrimidinyl]-p-hydroxybenzenesulfonamide, melting point 231°-232° C.

Quelle