Reaktion #413714

Reaktionsgleichung

6-chloro-2-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

methanol ammonia

→

2-iodoadenosine

Ausbeute 90.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction at a temperature of 60° C. for 17 hours in a sealed tube
2. 2
   TemperaturThe reaction solution was cooled
3. 3
   Sonstigedegassed
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeCrystallization of the residue from water

Vorschrift

6.0 g of 6-chloro-2-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine was added to 60 ml of methanol/ammonia (saturated at 0° C.) to cause reaction at a temperature of 60° C. for 17 hours in a sealed tube. The reaction solution was cooled, then degassed, and concentrated under reduced pressure. Crystallization of the residue from water afforded 3.94 g of 2-iodoadenosine (90% yield).

Quelle