Reaktion #413588

Reaktionsgleichung

3-(2-Amino-4-thiazolyl)alanine

L-glutamic acid

Methanol

→

3-(2-amino-4-thiazolyl)-L-alanine L-glutamic acid salt

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto crystallize the salt
2. 2
   Filtrationthe product is filtered
3. 3
   Waschenwashed with 40 L of methanol
4. 4
   SonstigeThe product is dried at 40° C. under vacuum

Vorschrift

DL-3-(2-Amino-4-thiazolyl)alanine, 41.8 kg (223 mol) (Silberg, A., et al, Chemische Berichte, Vol. 97, pages 1767-69 (1964)) and 26.3 kg (179 mol) of L-glutamic acid are dissolved in 620 L of water at 60° C. Methanol (620 L) is added to the solution and the solution is cooled to 25° C. to crystallize the salt. After stirring for 2 to 3 hours at 25° C., the product is filtered and washed with 40 L of methanol. The product is dried at 40° C. under vacuum to give 37.6 kg of 3-(2-amino-4-thiazolyl)-L-alanine L-glutamic acid salt as a white solid. Infrared spectrum (IR) (mineral oil): 2927 (s, br), 1643 (s), 1605 (s), 1548 (s), 1407 (sh) cm-1.

Quelle