Reaktion #41306

ord-99f35be9b4874ec3accc08ee17beeb82

Reaktionsgleichung

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
CCc1ccc[c]([Mg][Br])c1
(3-ethylphenyl)magnesium bromide
C1CCOC1
THF
→
CCc1cccc(C(=O)[C@H](C)NC(=O)OC(C)(C)C)c1
subtitle compound
CCc1cccc(C(=O)[C@H](C)NC(=O)OC(C)(C)C)c1
(S)-tert-butyl 1-(3-ethylphenyl)-1-oxopropan-2-ylcarbamate

Edukte

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
CCc1ccc[c]([Mg][Br])c1
(3-ethylphenyl)magnesium bromide
C1CCOC1
THF

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The subtitle compound was prepared analogous to the method described in Example 19 (step 19d). Starting from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (0.7 g, 3.01 mmol) and freshly made (3-ethylphenyl)magnesium bromide 0.9M solution in THF (5 mL, 4.50 mmol). Yield 817 mg (97%)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728030B2uspto-grants-2010_06