Reaktion #412994

Reaktionsgleichung

diethyl 2-(5-phthalimidopentyl)-2-propylmalonate

hydrochloric acid

→

desired compound

7-amino-2-propylheptanoic acid hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationinsoluble substance was remeved by filtration
3. 3
   EinengenThe filtrate was concentrated to dryness under reduced pressure
4. 4
   Sonstigethe residue was chromatographed on silica gel column
5. 5
   WaschenA fraction eluted with the upper phase of a mixture of butanol:acetic acid:water (4:1:5 volume by volume)
6. 6
   Einengenwas concentrated by dryness

Vorschrift

A mixture of diethyl 2-(5-phthalimidopentyl)-2-propylmalonate (6 g) and 26% hydrochloric acid (36 ml) was heated in a sealed tube at 190° C. for 4 hours. After cooling, insoluble substance was remeved by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was chromatographed on silica gel column. A fraction eluted with the upper phase of a mixture of butanol:acetic acid:water (4:1:5 volume by volume) was concentrated by dryness to give colorless sticky oil of the desired compound (yield 1.3 g).

Quelle