Reaktion #412951

ord-304a428e49ba483a847594332773dc38

Reaktionsgleichung

COC(=O)C(Br)CCBr
methyl 2,4-dibromobutyrate
CCOC(=O)C(C#N)C(C)c1ccccc1
Ethyl 2-cyano-3-phenylbutyrate
CCOC(=O)C(Cl)CCCl
ethyl 2,4-dichlorbutyrate
COC(=O)C(C#N)C(C)c1ccccc1
methyl 2-cyano-3-phenylbutyrate
CCOC(=O)C(CCCl)C(C#N)(C(=O)OCC)C(C)c1ccccc1
diethyl 2-phenyl-3-cyano-6-chlorohexane-3,4-dicarboxylate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigerespectively, in the alkylation reaction of Example 3

Vorschrift

Ethyl 2-cyano-3-phenylbutyrate and ethyl 2,4-dichlorbutyrate can be used in place of methyl 2-cyano-3-phenylbutyrate and methyl 2,4-dibromobutyrate, respectively, in the alkylation reaction of Example 3 to produce the corresponding diethyl 2-phenyl-3-cyano-6-chlorohexane-3,4-dicarboxylate. The latter product can then be reacted with the tricarboxylate of Example 4 and the dicarboxylate of Example 7 to give the corresponding pentaester and tetraester products.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04442298uspto-grants-1984_04