Reaktion #4122

ord-f25e64ba06b24bfdb0ae4125221bcb0b

Reaktionsgleichung

Cc1ccc2c(c1)CCCN2
6-methyl-1,2,3,4-tetrahydroquinoline
CN1CCN(C(=O)Nc2cc(F)ccc2N2CCc3ccccc32)CC1.O=C(O)/C=C\C(=O)O
1f
CN1CCN(C(=O)Nc2cc(F)ccc2N2CCc3ccccc32)CC1.O=C(O)/C=C\C(=O)O
N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate
O=[N+]([O-])c1ccccc1F
2-fluoronitrobenzene
Cc1ccc2c(c1)CCCN2c1ccccc1[N+](=O)[O-]
6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline
Cc1ccc2c(c1)CCCN2c1ccccc1N
1-(2-aminophenyl)-6-methyl-1,2,3,4-tetrahydroquinoline
Cc1cc2c3c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N3CCC2
5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Starting with 6-methyl-1,2,3,4-tetrahydroquinoline and 2-fluoronitrobenzene and following steps 1a to 1f of Example 2, one may obtain, in sequence, 6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-aminophenyl)-6-methyl-1,2,3,4-tetrahydroquinoline, N-[2-(6-methyl-1-phenyl)-1,2,3,4-tetrahydroquinolin-1-yl]-4-methyl-1-piperazine carboxamide, and 5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04723007uspto-grants-1988_02