Reaktion #41210

Reaktionsgleichung

butynyl bromide

hydroquinone

K2CO3

→

crude product

Ausbeute 25.0%

4-But-2-ynyloxy-phenol

Ausbeute 25.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 10 h
2. 2
   SonstigeSolvent was removed in vacuo
3. 3
   workup.DISSOLUTIONthe crude product was dissolved in EtOAc
4. 4
   Sonstigepartitioned with water
5. 5
   SonstigeOrganic layer was separated
6. 6
   Waschenwashed with water
7. 7
   Trocknendried over anhydrous Na2SO4
8. 8
   SonstigeThe solvent was removed in vacuo

Vorschrift

To a solution containing butynyl bromide (1 g, 7.5 mmol), hydroquinone (827 mg, 7.5 mmol), and K2CO3 (1.04 g, 7.5 mmol) was refluxed for 10 h. Solvent was removed in vacuo and the crude product was dissolved in EtOAc and partitioned with water. Organic layer was separated and washed with water and dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the crude product (0.3 g, 25%), which was used for the next step without further purification; LCMS 99%, m/z 162.2 (M+).

Quelle