Reaktion #411990

Reaktionsgleichung

2,6-diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-(4-methyl-1-pentenyl)pyridine

2,6Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-(4-methyl-1-pentenyl)pyridine

→

title compound

2,6-Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-(4-methylpentyl)pyridine

Lösungsmittel

ethyl acetate hexane

Reaktionsbedingungen

Vorschrift

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-(4-methyl-1-pentenyl)pyridine (Example 28) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.14 (m, 4 H), 4.33 (d, J=5 Hz, 2 H), 3.41 (sept, J=6.6 Hz, 1 H), 3.22 (sept, J=6.6 Hz, 1 H), 2.23 (m, 2 H), 1.38 (m, 1 H), 1.33 (d, J=6.6 Hz, 6 H), 1.30 (d, J=6.6 Hz, 6 H), 1.27 (m, 1 H), 1.17 (m, 1 H), 1.00 (m, 3 H), 0.76 (d, J=6.6 Hz, 6 H). FAB-MS: calculated for (C24H34FNO) 371, found 372 (M+H). Anal. Calcd for C24H34FNO: C, 77.59; H, 9.22; N, 3.77. Found: C, 77.63; H, 9.39; N, 3.58. mp 101-103° C. Rf=0.3 (20% ethyl acetate/hexane).

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