Reaktion #411988

Reaktionsgleichung

2,6dusopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5ethenylpyridine

2,6Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-ethenylpyridine

→

title compound

2,6Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-ethylpyridine

Lösungsmittel

ethyl acetate hexane

Reaktionsbedingungen

Vorschrift

The title compound was prepared from 2,6dusopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5ethenylpyridine (Example 22) according to the procedure described in Example 1, Step H. 1H NMR (300 MHz, CDCl3): δ7.15 (m, 4 H), 4.33 (d, J=3.6 Hz, 2 H), 3.41 (sept, J=6.6 Hz, 1 H), 3.26 (sept, J=6.6 Hz, 1 H), 2.34 (q, J=7.35 Hz, 2 H), 1.33 (d, J=6.6 Hz, 6 H), 1.31 (d, J=6.6 Hz, 6 H), 1.19 (m, 1 H), 0.93 (t, J=7.35 Hz, 3 H). FAB-MS: calculated for (C20H26FNO) 315, found 316 (M+H). Anal. Caled for C20H26FNO: C, 76.16; H, 8.31; N, 4.44. Found: C, 75.74; H, 8.50; N, 4.27. mp 126-129° C. Rf=0.4 (20% ethyl acetate/hexane).

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