Reaktion #41186

Reaktionsgleichung

tert-butyl nitrite

acetic acid

5-amino-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester

hydrochloric acid

→

5-chloro-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Ausbeute 30.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added over 10 minutes
2. 2
   ExtraktionThe aqueous layer was extracted with methylene chloride (2×100 mL)
3. 3
   Trocknendried over anhydrous sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in vacuo
6. 6
   Sonstigeto provide the crude material
7. 7
   SonstigeThe product was purified by column chromatography on silica gel (eluting with ethyl acetate/hexanes, 1:1)

Vorschrift

To a mixture of 5-amino-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester (5.22 g, 23.0 mmol) in dry acetonitrile (46 mL) was added anhydrous cuprous chloride (3.73 g, 37.7 mmol) and acetic acid (2.6 mL, 46.0 mmol). The mixture was cooled to 0° C. in an ice-water bath after which tert-butyl nitrite (4.9 mL, 36.8 mmol) was added over 10 minutes. The solution was allowed to warm to room temperature and stir for 4 h. To the solution was carefully added 6.0N hydrochloric acid (20 mL). The aqueous layer was extracted with methylene chloride (2×100 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide the crude material. The product was purified by column chromatography on silica gel (eluting with ethyl acetate/hexanes, 1:1) to provide 5-chloro-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1.71 g, 30%) as an orange oil. Mass spectrum: m/z: 247.3 (M+1).

Quelle