Reaktion #41157

Reaktionsgleichung

t-Butyl nitrite

5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

HCl

→

5-chloro-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

Ausbeute 42.0%

Lösungsmittel

acetonitrile

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 70° C. for 1.25 hour
2. 2
   TemperaturThe mixture was cooled to room temperature
3. 3
   Extraktionextracted with methylene chloride
4. 4
   WaschenThe organic phase was washed sequentially with water and brine
5. 5
   ExtraktionThe aqueous phases were back extracted with a second portion of methylene chloride
6. 6
   Trocknendried over sodium sulfate
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeThe crude residue was chromatographed by flash chromatography
9. 9
   Wascheneluting with a gradient of 10-50% ethyl acetate/hexanes

Vorschrift

Copper(I) chloride (2.500 g, 25.25 mmol) was suspended in 7.0 mL cold (ice/acetone bath) anhydrous acetonitrile. t-Butyl nitrite (5.75 mL, 90%, 43.56 mmol) was added, followed by a suspension of 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (4.408 g, 18.58 mmol) in 27.0 mL acetonitrile. The mixture was stirred at room temperature for 45 minutes and then at 70° C. for 1.25 hour. The mixture was cooled to room temperature, slowly added to 6N HCl (17.5 mL) and then extracted with methylene chloride. The organic phase was washed sequentially with water and brine. The aqueous phases were back extracted with a second portion of methylene chloride. The two organic phases were combined, dried over sodium sulfate and concentrated in vacuo. The crude residue was chromatographed by flash chromatography eluting with a gradient of 10-50% ethyl acetate/hexanes to give 5-chloro-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.98 g; 42%). Mass spectrum: m/z: 257.3 (M+H).

Quelle